Research

Our clinic has a strong research interest and we aim to progress the understanding and treatment of Tourette Syndrome through clinical research.  Some of our current research projects include:

1. Creation of a Disease Specific Quality of Life Instrument for Children with Tourette Syndrome
2. Defining and measuring rage/explosive anger in children with Tourette Syndrome and other neuropsychiatric disorders
3. Predicting outcome in Tourette Syndrome; identifying factors present early in life which predict resolution of tics in adulthood
4. Understanding the links between Tourette Syndrome and difficulties with social communication  

Trials

Our clinic will be participating in multicentre clinical trials of new drugs for patients with Tourette Syndrome. Please see below for current research studies:

1) Title: Pilot Study to Monitor the Safety of Second Generation Antipsychotic Medications in Children
 
Dr. Tamara Pringsheim and the CAMESA Guideline Group have created evidence-based preliminary guidelines for monitoring the safety and effectiveness of Second Generation Antipsychotics (SGAs) in children. SGA medications are used to treat several disorders in children, including aggressive behaviour in children with ADHD, oppositional defiant and conduct disorders, behavioural problems in children with autism spectrum disorders, tic disorders, mood disorders, and psychosis. While SGAs are often effective, they also may have side effects such as weight gain, increased blood glucose, higher blood cholesterol levels, and involuntary movements. The purpose of this pilot study is to test these preliminary guidelines, to determine if they are appropriate and feasible in the real world setting.
 
We are currently recruiting patients at the Child Development Centre for this study. The only inclusion criterion is that a patient is newly prescribed an SGA medication for any reason. It is a 6 month long study, with the following required study visits: pre-treatment baseline, and 1 month, 2 month, 3 month, and 6 month follow-up visits. During the study visits patients would have a clinic appointment with their regular physician to assess the status of their disorder and the efficacy of their SGA medication, including potential side effects. In addition, patients would also be assessed by Dr. Pringsheim and/or the clinic nurse to get physical measurements (height, weight, waist circumference, and blood pressure) taken, and have a brief neurological exam. Blood work would be required at baseline, and possibly at the 3 and 6 month follow-up visits. Please contact Dr. Pringsheim at tmprings [at] ucalgary [dot] ca if you have any queries about this study."

Updated: 10.19.2011